Inositec’s INS-3001 Significantly Reduces Cardiovascular Calcification in Proof-of-Concept Studies Published in Nature Communications

Zurich, Switzerland, February 5, 2020 – Inositec, a pioneer in the development of life-saving small molecule drugs based on myo-inositol hexaphosphate (IP6), announced today that positive proof-of-concept data on INS-3001, a novel cardiovascular calcification inhibitor, were published in Nature Communications (DOI: 10.1038/s41467-019-14091-4). INS-3001 was found to be a potent and well tolerated inhibitor of pathological soft tissue calcification in preclinical studies. Calcification, particularly in arterial walls and cardiac valves, leads to an increase in cardiac events. Inositec is developing INS-3001 for a number of cardiovascular indications caused by calcification, including aortic valve stenosis.

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JenaValve Technology Closes $50 Million Financing

Irvine, Calif. (February 5, 2020) – JenaValve Technology, Inc., developer and manufacturer of the JenaValve Pericardial Transcatheter Aortic Valve Replacement (TAVR) System for the treatment of aortic valve disease, announces that it has raised $50 million in an equity financing led by Bain Capital Life Sciences. Additional participants in the financing included existing investors Andera Partners, Gimv, Legend Capital, NeoMed Management, RMM, Valiance Life Sciences and VI Partners. The Company also announces the appointment of Andrew Hack, MD, PhD, Managing Director of Bain Capital, to the JenaValve Board of Directors.ith Merck and Cancer Research UK providing a best-in-class pipeline of molecules that harness both direct and immune-mediated anti-cancer activities in solid cancers and cancer fibrosis.

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Sequana Medical announces first patient enrolled in RED DESERT – REpeated Dose alfapump® DSR study for Treatment of diuretic-resistant heart failure patients

The study aims to:

  • Evaluate the safety of alfapump DSR in patients with heart failure
  • Assess the feasibility of alfapump DSR to remove excess sodium and fluid from the body
  • Explore the potential impact of DSR therapy to restore response to diuretics

Ghent, BELGIUM – 7 January 2020 – Sequana Medical NV (Euronext Brussels: SEQUA), an innovator in the management of fluid overload in liver disease, malignant ascites and heart failure, today announces that the first patient has been enrolled in the first-in-human repeated dose study of alfapump DSR (Direct Sodium Removal) for the treatment of diuretic-resistant heart failure patients.

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La start-up Gamaya lève 12 millions de francs

Gamaya, active dans l’agriculture de précision, a levé 12 millions de francs dans le cadre d’un tour de financement de série B, dont 4,2 millions de francs sous forme d’obligations convertibles. Un tournant pour cette spin-off de l’EPFL.

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SumUp received a $371M loan to fuel its expansion

SumUp Inc., a six-year-old electronic payments startup, secured a 330 million-euro ($371 million) loan, backed by Bain Capital Credit, Goldman Sachs Private Capital and others. The London-based company plans to boost its customer base across 31 markets and develop its range of products, including via acquisitions.   (more…)

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